Multiple sleep latency test and polysomnography in patients with central disorders of hypersomnolence

A multiple sleep latency test (MSLT) with occurrence of onset REM periods (SOREMP) is considered one the central diagnostic criteria for narcolepsy according to International Classification Sleep Disorders, but its sensitivity and specificity have been questioned. This study aims describe MSLT polysomnography (PSG) findings, including frequency distribution SOREMP during day, in a large cohort patients disorders hypersomnolence (CDH). We retrospectively analyzed electrophysiological data from PSG 370 consecutive type 1 (NT1, n = 97), 2 (NT2, 31), idiopathic hypersomnia (IH, 48), nonorganic (NOH, 116) insufficient syndrome (ISS, 78). NT1 NT2 had significantly shorter mean Latency (mSL) REM-Latency (REML) PSG. occurred more frequently narcoleptic vs. non-narcoleptic Occurrence 3 or very high positive predictive value (98%/96% 100% respectively), however relatively low (65% 45% respectively). than mSL frequent SL as well REML nocturnal Increasing numbers especially increase on expense diagnosing narcolepsy. Therefore, naps can help discriminate not clearly separate patients.